Validation of multiple breath washout devices

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Equipment for multiple breath washout.

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Validation of multiple-breath washout equipment: from bench to clinic and possible pitfalls.

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A Realistic Validation Study of a New Nitrogen Multiple-Breath Washout System

BACKGROUND For reliable assessment of ventilation inhomogeneity, multiple-breath washout (MBW) systems should be realistically validated. We describe a new lung model for in vitro validation under physiological conditions and the assessment of a new nitrogen (N(2))MBW system. METHODS The N(2)MBW setup indirectly measures the N(2) fraction (F(N2)) from main-stream carbon dioxide (CO(2)) and si...

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In vitro and in vivo functional residual capacity comparisons between multiple-breath nitrogen washout devices

Functional residual capacity (FRC) accuracy is essential for deriving multiple-breath nitrogen washout (MBNW) indices, and is the basis for device validation. Few studies have compared existing MBNW devices. We evaluated in vitro and in vivo FRC using two commercial MBNW devices, the Exhalyzer D (EM) and the EasyOne Pro LAB (ndd), and an in-house device (Woolcock in-house device, WIMR). FRC mea...

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Impact of Software Settings on Multiple-Breath Washout Outcomes

BACKGROUND AND OBJECTIVES Multiple-breath washout (MBW) is an attractive test to assess ventilation inhomogeneity, a marker of peripheral lung disease. Standardization of MBW is hampered as little data exists on possible measurement bias. We aimed to identify potential sources of measurement bias based on MBW software settings. METHODS We used unprocessed data from nitrogen (N2) MBW (Exhalyze...

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ژورنال

عنوان ژورنال: Journal of Cystic Fibrosis

سال: 2017

ISSN: 1569-1993

DOI: 10.1016/j.jcf.2017.01.011